I read this for a brain science and pedagogy. It was a wealth of information on the brain. Absolutely fascinating, yet had to reread some sections because it was hard for me to comprehend. The best part is how he intertwined his life story into his studies of the brain. Fascinating!

I'm taking a course at Oxford this summer on "The Brain and the Senses." So this is a little extra homework. The idea of memory, where thoughts come from, etc., is fascinating to me. And, many years ago, before I was there, Kandel had his laboratory at the Public Health Research Institute, of which I was later CEO. I'll post more when I get into it.I HAVE NOW COMPLETED BOTH THE COURSE AND KANDEL'S BOOK.BOTH WERE TERRIFIC!The course, offered by Oxford tutor Gillie McNeill, combined descriptions of sensory processes with an explanation of the underlying molecular activity that integrates the incoming perceptions and what's already in memory to create a coherent narrative.We started by eating a cracker and considering what was involved in our individual perceptions of that event ... taste, smell, sight, feel, sound, and memory of crackers and herbs previously ingested. Quite a bit for the first few minutes of the course.Kandels book offers enchanting glimpses of his life story, the history of brain psychology and science, and a description of the experiments (of Kandel and others) which are moving our understanding of the brain forward at an incredible pace while also revealing just how little we still know.Kandels decision, early in his career, to begin his lifes work with the study of a single cell, set the stage for the way he approached his work. He decided to study the giant marine snail Aplysia as his first means to understand how information was brought into a cell and transferred out to another cell. Learn how that happens, multiply by tens of billions, and you have a working human brain.These quotes may communicate the excitement of Kandels journey (which by the way led to a Nobel prize)...the realization that the workings of the brain - the ability not only to perceive but to think, learn, and store information - may occur through chemical as well as electrical signals expanded the appeal of brain science from anatomists and electro-physiologists to biochemists.I was testing the idea that the cellular mechanisms underlying learning and memory are likely to have been conserved through evolution and therefore to be found in simple animals.We pointed out the importance of discovering what actually goes on at the level of the synapse (the place where signals are passed from one cell to another) when behavior is modified by learning.This last quote is almost a synopsis of what the course at the Oxford Experience was about. It turns out that there is considerable growth and change in the brain connections and that this goes on all the time. Your brain has changed since you started reading this review.

This was an excellent read for me on several levels. I picked it up to learn to more about the science behind the formation of short and long term memories and was not disappointed. Dr. Kandel undertakes the task of explaining the scientific research in neurology and the mind to which hes devoted his life. He succeeds admirably at making his descriptions simple enough for a general reader for whom high school or college biology may be a distant memory. What I hadnt expected to find were the biographical details that showed how the memory of fleeing Austria with his family as a child to escape the Nazi regime affected the author his entire life. He also describes his efforts to make the current Austrian government and scientific community acknowledge Austrias role in the Holocaust. Another aspect of the book that I enjoyed were the authors descriptions of a life spent doing science. He is generous in his praise of colleagues and seems to have had no trouble navigating the politics of an academic career. Finally, I was touched by the love and respect with which he spoke of his wife Denise, who made sacrifices scientific career to shoulder most of the responsibility for raising their two children while he devoted himself to his passion for scientific discovery.